Toxicology Studies

Toxicology Studies

Rodenta Bioserve is a DCA GLP compliant contract research facility dedicated to accelerating drug development and preclinical studies. With a team of interdisciplinary researchers and state-of-the-art facilities, we offer a comprehensive range of pharmacology and toxicology services to meet the diverse needs of our clients.

Our scientists conduct a range of acute, sub-chronic and chronic toxicity tests for assessing drug toxicity. While, Acute toxicity studies are conducted to determine the short-term adverse effects of a drug which is administered either as a single dose or as a divided doses in a period of 24 hours, while sub chronic toxicity studies are conducted to determine the toxicity of test compounds after repeated administration of small doses. The adverse effects of the test compound’s following prolonged repeated exposure is determined by chronic toxicity studies.

  • Acute Toxicity Studies: Determining short-term adverse effects of a drug through single or divided doses within 24 hours.
  • Sub-Chronic Toxicity Studies: Assessing toxicity after repeated administration of small doses.
  • Chronic Toxicity Studies: Evaluating adverse effects following prolonged repeated exposure.
  • Single Dose/6 Pack Studies
  • Oral Toxicity: Including acute oral toxicity, maximum tolerable dose range finding studies, and more.
  • Inhalation Toxicity
  • Dermal Toxicity: Assessing single dose dermal toxicity and skin irritation.
  • Skin Sensitization Studies
  • Eye Irritation Studies

Repeated Dose (RD) Toxicity (OECD 407, 408)

  • Chronic toxicity (CT)
  1. 6-12 months CT in rat & mice (OECD 452)
  2. Carcinogenecity study in rat & mice (OECD 451, 453)

Chronic toxicity (CT)

  • Developmental & Reproductive Toxicity (DART)
  1. Prenatal developmental toxicity in rats & rabbit by OECD 414
  2. Prenatal & postnatal developmental toxicity in rat & mice by ICH guidelines
  3. Neonatal toxicity in rat & mice
  4. Reproductive & developmental toxicity in rat by OECD 421, 422
  5. Male fertility study in rat

Developmental & Reproductive Toxicity (DART)

Pyrogen testing in rabbit model

  • Genotoxicity
  1. Mouse erythrocyte micronucleus test (In vivo) by OECD 474
  2. AMES Test (Bacterial reverse mutation) by OECD 471
  3. Chromosomal aberration test (In vivo) by OECD 475

Pharmaco-kinetics & Toxic-kinetics in rodent models

  • Pharmacology studies in disease animal models
  1. Diabetes models
  2. Oncology models
  3. Inflammation models
  4. Obesity models

Efficacy (In vivo pharmacology)

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